Topical glyceryl trinitrate relaxes the sphincter of Oddi.

Topical glyceryl trinitrate relaxes the sphincter of Oddi.

BACKGROUND/AIM Nitric oxide (NO) may be involved in non-adrenergic non-cholinergic (NANC) inhibitory innervation of the sphincter of Oddi (SO). The effects of topical application of glyceryl trinitrate (GTN), a NO donor, upon SO motility were examined. METHODS Nineteen patients undergoing routine SO manometry for investigation of abdominal pain were studied. After routine recording of SO moti...

Topical glyceryl trinitrate in the treatment of anal fissure.

AIM the aim of this study was to assess the effectiveness of topical glyceryl trinitrate (GTN) in the treatment of anal fissure. PATIENTS eighty consecutive patients were randomized to receive 0.2% GTN gel twice a day during a minimum of 6 weeks. Of these 80 patients 34 were males and 46 female, with ages between 20 and 78 years. All patients underwent a work-up that included gender, age, sym...

Topical Diltiazem versus topical Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: Prospective study

Comparison with glyceryl trinitrate

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

Sphincter of Oddi Dysfunction

INTRODUCTION Sphincter of Oddi dysfunction (SOD) is a benign acalculous obstruction to the flow of biliopancreatic secretions through the sphincter of Oddi (1,2). In the general population, its prevalence is 1.5% (3). It is one of the known causes of post-cholecystectomy syndrome, and is observed in 14%–23% of these patients (4,5). The post-cholecystectomy syndrome can loosely be defined as a p...